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Elevated TMAO levels have been associated with increased risks of atherosclerosis, cardiovascular disease, and higher all-cause mortality in multiple epidemiological studies

It also reduces fatigue in early-stage ovarian cancer cachexia, suggesting potential for early therapeutic intervention (Tsitkanou et al., 2024)

Listed below are the on-label (approved) uses and off-label (unapproved) uses

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Chronic glutathione depletion is documented in HIV/AIDS (where low GSH correlates with disease progression), Parkinsons disease (substantia nigra GSH levels are 40% lower than controls), non-alcoholic fatty liver disease, cystic fibrosis, and acute respiratory distress syndrome